OVERVIEW
Small molecule medicinal chemistry and structure-based drug design consultants with expertise in multiple disease areas and particular expertise in antibacterial, anticancer, central nervous system disorders and cardiovascular disease. Former research directors from major pharmaceutical (Merck, Aventis, Johnson & Johnson) and biotech (Myogen, Replidyne, & Gilead) companies.
DETAILED SERVICES
Rational molecule selection for lead identification, scaffold hopping, or lead optimization. Lead optimization and ligand design using classical medicinal chemistry and structure-based design techniques, including fragment-based approaches. Intellectual property analysis and assistance with patent submission. Strategic advice and input with grant solicitations.
PRINCIPLES
- Dr. Laurie Castonguay is the co-founder and President of Ency2 Consulting. She was the director of computational chemistry at Merck Research Laboratories and was most recently at Myogen and Gilead.
- Dr. Joseph Guiles is the co-founder of Ency2 Consulting. He is presently General Manager of CedarburgHauser Pharmaceuticals in Denver, Colorado. He was formerly director of chemistry at Replidyne, Aventis, and Johnson & Johnson.